The key players within the pathways of RNA decay are well conserved with their mutation or disruption resulting in distinct phenotypes as well as human disease.
Life Science
Insights Into The Control Of Trypanosome Editing
Specific examples of complex variants, differential effects of editing proteins on the mRNAs within and between T. brucei life stages, and possible control points in the holo-editosomes are examined.
Welcome to the Health, Medical and Life Sciences Virtual Issue for Advanced Science
A collection articles that highlight the outstanding work in the areas of Health, Medical and Life Sciences published in Advanced Science.
Using Raman Spectroscopy To Assess Brittle Bones
A team of American researchers tested the possibilites of using Raman spectroscopy to assess collagen structure or collagen integrity in bone.
Keep the Plasmid Party Rolling, But Keep it Cool with Structured Antisense RNAs
Bacterial plasmids constitute a wealth of shared DNA amounting to about 20% of the total prokaryotic pangenome. Plasmids replicate autonomously and control their replication by maintaining a fairly constant number of copies within a given host. Plasmids should acquire a good fitness to their hosts so that they do not constitute a genetic load.
Along The Way: Combining RNA-Seq and Lineage Tracing to Map Developmental Lineage Trajectories
In their review published in BioEssays, Russell Fletcher, Diya Das and John Ngai discuss how the integration of lineage tracing with data obtained from single-cell RNA-sequencing can provide insights into how stem cells differentiate.
Branching Out: Neuronal Growth Modifiers
Using nano-pillars to change the way that neurons grow.
Computational Methods for Analyzing and Modeling Genome Structure and Organization
Recent advances in chromosome conformation capture technologies have led to the discovery of previously unappreciated structural features of chromatin.
From Microbes and Fetal Allografts to a Better Understanding of Cancer Immune Tolerance
In their ‘Think again’ article published in BioEssays, Megan Barnet and colleagues discuss how insights from fetal allografts and microbes can lead to a better understanding of immune tolerance in cancer.
Control of Protein Synthesis During the Integrated Stress Response
The integrated stress response (ISR) is a highly-conserved pathway used by cells to respond to diverse cellular stresses.
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