While it might not feel like it, the cells in our body are under constant stress. Cellular exposure to stress such as UV radiation contributes to DNA lesions that the cell responds to by initiating DNA repair pathways. If these lesions are not dealt with, mutations...
Understanding the nature and origin of the non-coding genome.
American scientists demonstrated the utility of SERS measurements of urine from deceased donors and associated PCA-LDA analysis as a potential tool to predict kidney transplant outcomes.
Internal ribosome entry sites (IRES) are used by some viruses to hijack the host cellular translation machinery for their own translation.
Pattern regulation, as observed in regeneration and development, enables cells to cooperate toward the creation and maintenance of complex anatomies. This image shows planaria, of which every piece has the information needed to restore a complete planarian target morphology.
The RNA-binding protein vigilin is conserved from yeasts to humans. Through 30 years of study, vigilin has been associated with a variety of cellular functions both in the nucleus and in the cytoplasm.
A new in vivo strategy for displaying foreign polypeptides on magnetosomes is presented.
A novel, nature template-based computation design method has been proposed, and demonstrates the potential for design of peptides for chemical biology and medicinal chemistry.
Recent knowledge about metamorphosis and adult organ formation of ascidians is reviewed, in order to elucidate the molecular similarities with those in vertebrates.
Polypeptides have a rich variety of structures and functions. Their chemoenzymatic synthesis is reviewed by the Enzyme Research Team at RIKEN, Japan.
Serotonin neurons are highly plastic; their development, maturation and regeneration is controlled by a complex gene regulatory network in constant interaction with the environment. An overview article recently published in WIREs Developmental Biology offers an updated view of these fundamental developmental mechanisms, pointing to the many ways by which developmental dysfunction of serotonin systems might occur at different periods in life. This opens new possibilities for therapeutic intervention, which can range from prevention of risk to stem cell therapies.
PROTEOMICS is inviting papers for a Special Issue on Omics insights into (nano)materials–organism interactions.