Targeted viral-based gene therapies come with their own risks. A new gene delivery system mimics viral therapies to infect cancer cells with vesicular stomatitis virus matrix protein, with a similar transfection efficiency as the virus itself.
Life Science
Why Dominant Individuals are More Vulnerable to Develop Stress-Induced Depression
Thomas Larrieu and Carmen Sandi discuss whether social rank is a predictive risk factor for stress-induced depression.
Simulating Complex Systems: Agent-based Modeling in Molecular Systems Biology
Mohammad Soheilypour and Mohammad Mofrad discuss a technique termed ‘agent-based modeling’ that is used in systems biology.
Stacking Up: Building Complex Perfused Tissues
An automated system to assemble macrotissues from prefabricated living microtissues with a cell density similar to organs is reported.
New Ultra‐Low‐Cost Smartphone Sensor To Diagnose Autoimmune Disease
American researchers designed a smartphone octo‐channel optosensor (SOS) for low‐cost low‐volume lab tests as a mHealth diagnostic tool.
Linking Mitochondrial ROS to Synapse Pruning
In his “Hypotheses“ article, James Cobley links mitochondrial ROS to activity-dependent synapse pruning.
Tales Around the Clock: poly(A) Tails in Circadian Gene Expression
Light is perhaps the main environmental cue (zeitgeber) that affects several aspects of physiology and behaviour, such as sleep/wake cycles, orientation of birds and bees, and leaf movements in plants. Temperature can serve as the main zeitgeber in the absence of light cycles, even though it does not lead to rhythmicity through the same mechanism as light.
Get Your Sunglasses Out: UV-Radiation and Eye Health
A German team of scientists published an overview on all the most recent knowledge on the role of the ultraviolet radiation in eye health and its aging process.
Shucks, Shellfish Allergies are Complex
The mechanisms at play in shellfish allergies are put under the grill.
The Mechanistic Basis for Chromatin Regulation by Pioneer Transcription Factors
An investigation into how pioneer factors interact with closed chromatin to influence chromatin landscapes and generate differentiated cells.
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