Although the overall functionality of Cas9 and Cas12a is remarkably similar, their distinct structural features result in distinct molecular mechanisms that impact their activities.
Biotechnology
Seeing from a Nanoelectrochemical Confined World
Electrochemical confined effects are capable of exploring the novel detection mechanisms of nanopore to efficiently convert the dynamic function/structure of single molecules into the ionic signatures or optical patterns. This will prompt the nanopore to emerge on the comprehensive range of future applications in both life and material science.
CRISPR-based Genome Editing via Non-Viral Delivery
This non-viral CRISPR-Cas9 delivery vector is ten times as effective at genome modification as the standard plasmid transfection techniques, down-regulating Plk1 expression over 70% to inhibit tumor growth.
![Microbial Sensors Based on ZnO Nanorod Arrays [Video]](https://www.advancedsciencenews.com/wp-content/uploads/2018/05/adfm201706309_ASN_image.jpg)
Microbial Sensors Based on ZnO Nanorod Arrays [Video]
The size, shape, and order of nanorods in solid-state microbial sensors are controlled using the forces of gravity and magnetism.
Invader Cells as Delivery Vesicles for Various Cargo Molecules
A smart cell-targeting approach for potential use in specific cell ablation.
Electrical Neurostimulation as Artificial Retina
Stimulation of nerves by an artificial retina toward therapeutics for blindness.
Targeting RNA in Mammalian Systems with Small Molecules
Small molecules have been used to study several mammalian RNA elements in disease. These advances encourage exploration of newly discovered RNA interactions with therapeutic potential.
Switch the Photosensitizer On!
A strategy to transform various photosensitizers into activatable ones for photodynamic therapy is reported.
Nanoscale Platforms for Messenger RNA Delivery
An overview of the most recent literature relevant to mRNA delivery helps readers to obtain an overall concept and direction of nanoscale platforms for mRNA delivery.
Cover Art – Microrobots for Cell & Drug Delivery and Synthetic Cells
Check out the latest covers of Advanced Healthcare Materials!
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