Although many eukaryotic transcripts contain cap structures, it has been long thought that bacterial RNAs do not carry any special modifications on their 5′‐ends. In bacteria, primary transcripts are produced by transcription initiated with a nucleoside triphosphate and are therefore triphosphorylated on 5′‐ends.
Insights for Heart Repair
The Hippo pathway’s role in heart development and regeneration.
Context-Dependent Regulation of Receptor Tyrosine Kinases
Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the ability to sense proteins in their environments. Many RTKs are essential to development and organ growth. Derangement of RTKs—by mutation or by overexpression—is central to several developmental and adult disorders including cancer, short stature, and vascular pathologies.
Synthesis and Degradation of RNAs: A Fundamental Aspect of Gene Regulation
Organisms have acquired sophisticated regulatory networks that control gene expression in response to cellular perturbations. Understanding of the mechanisms underlying the coordinated changes in gene expression in response to external and internal stimuli is a fundamental issue in biology.
Disassembling Solvation Free Energies into Local Contributions
Solvation free energies contribute to the driving force of molecular processes in solution and play a significant role for the relative stability of biomolecular conformations or the formation of complexes. Changes in solvation free energy are the origin of solvent‐mediated interactions such as the hydrophobic effect in water.
Environmental Influences On RNA Processing: Regulators Of Cellular Response
RNA processing has emerged as a key mechanistic step in the regulation of the cellular response to environmental perturbation.
Interview with Prof. John Ohlrogge: Understanding the Plant Lipid Metabolism Pathways
John shares his thoughts on his research, his effort on the on-going PlantFAdb database, his suggestions to early-career scientists, and the challenge in the future plant lipid metabolism research.
Exploring the Effect of Vitamin E in Cancer Chemotherapy
New research from India shows that vitamin E may prove beneficial to alleviate chemotherapy associated side effects in cancer patients.
Bioinspired 3D Matrices: The Role of the Microniche in Controlling Cell Function
How best to engineer synthetic microenvironments for developing and maintaining living tissues inside synthetic compartments is discussed.
Expand Your Mind: Development of a Hybrid Biomicroscope for the Brain
A hybrid dual‐wavelength optoacoustic biomicroscope is developed to provide better insights into cerebrovascular function and facilitate efficient studies into neurological and vascular abnormalities of the brain.