Chunmeng Shi and co-workers from the Third Military Medical University in Chongqing, China, introduce a small-molecule-based cancer theranostic agent for simultaneous cancer-cell mitochondrial targeting, NIR imaging, and chemo-/PDT/PTT/multimodal therapeutic activities.
Immunity to CRISPR Cas9 and Cas12a Therapeutics
Genome-editing therapeutics introduce foreign nucleic acids and proteins into the circulation and cells, which can activate the innate, cellular, and humoral immunity in human patients. The key obstacle in translating CRISPR therapeutics to the clinic is hence to identify, diminish, and monitor these immunological risks before adverse immune reactions.
From Polymers to Functional Biomaterials
A new special issue in Macromolecular Bioscience highlights emerging applications of polymers for the synthesis of functional biomaterials.
Safe Smiling: Bleaching Teeth Using Plasma Jet
Taiwanese scientists create a new atmospheric-pressure plasma jet tooth bleaching method that is safe, cost effective and portable.
Influenza Antiviral Agent Regulates ROS
Polymeric nanoparticles acting as intracellular ROS regulators show promise as antiviral agents in influenza-infected kidney cells.
Single Cell Transcriptomics of Non-Coding RNAs and their Cell-Specificity
Non-coding RNA expression varies at the single cell level, at least as much variability as protein-coding RNA, and some classes of non-coding RNA may display more single cell variability.
Ancient and Modern Hints: Chemotherapy Resistance in Ovarian Cancer
RNA-binding proteins influence epithelial ovarian cancer progression through complex networks with mRNAs, non-coding RNAs and other proteins.
Serotonin Neuron Development: Shaping Molecular and Structural Identities
Serotonin neurons are highly plastic; their development, maturation and regeneration is controlled by a complex gene regulatory network in constant interaction with the environment. An overview article recently published in WIREs Developmental Biology offers an updated view of these fundamental developmental mechanisms, pointing to the many ways by which developmental dysfunction of serotonin systems might occur at different periods in life. This opens new possibilities for therapeutic intervention, which can range from prevention of risk to stem cell therapies.
RNA Nanotechnology and Biomedical Applications: RNA Versatility, Flexibility and Thermostability
Recent advances in fabricating RNA nanostructures are highlighted, including their applications in vivo as imaging or therapeutic devices via specific delivery and targeting, or intracellular expression and assembly.
Cellular Therapeutics: Small Molecule Signaling, Regulation, and Potential Applications
Small molecules have many important roles across the tree of life.