Life Science
Dynamic Enhancer Function in the Chromatin Context

Dynamic Enhancer Function in the Chromatin Context

In live cells, many enhancer-binding transcription factors exchange rapidly with their binding sites and leave no footprints in chromatin. Available data suggests a highly dynamic mechanism for enhancer activation, involving numerous stochastic binding events at a target enhancer.

The Best Models of Metabolism

The Best Models of Metabolism

This Review outlines the metabolic model design process and discusses the numerous choices for modeling frameworks and mathematical representations.