In today’s fast-changing scientific landscape, interdisciplinary fields are the new normal and clinical trials for new therapies are exploding. On the scientific information side, the WIREs series presents current, comprehensive reviews of the pioneering research that...
Researchers in Italy introduce the problems and the reasons behind the need for different simulation strategies and they guide the reader through the pros and the cons of each method with respect to the others.
Agent-based models are a form of “bottom-up” modeling, which means that models are based on individual actors.
How T cells maintain homeostasis and maximize the size of the peripheral T cell pool are important questions that have fascinated both immunologists and mathematicians.
Recent advances in single‐molecule techniques have led to new discoveries in analytical chemistry, biophysics, and medicine. Understanding the structure and behavior of single biomolecules provides a wealth of information compared to studying large ensembles.
Polymer physics is the basis to models that explain chromatin folding mechanisms.
Synergistic developments in advanced fluorescent imaging and labeling techniques enable direct visualization of the chromatin structure and dynamics at the nanoscale level and in live cells.
All organisms are subject to large amounts of genetic and environmental variation and have evolved mechanisms that allow them to function well in spite of these challenges. This property is generally referred to as robustness.
Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the ability to sense proteins in their environments. Many RTKs are essential to development and organ growth. Derangement of RTKs—by mutation or by overexpression—is central to several developmental and adult disorders including cancer, short stature, and vascular pathologies.
Mammalian barrier surfaces are densely populated by symbiont fungi in much the same way the former are colonized by symbiont bacteria. The fungal microbiota, otherwise known as the mycobiota, is increasingly recognized as a critical player in the maintenance of health and homeostasis of the host.
Do vitamins prevent cancer and heart disease?
Understanding the science behind the neon shortage
In situ cancer vaccine captures antigens from tumors
Artificial heart valves that evolve into a patient’s own tissue
Endometriosis treated by heating magnetic nanoparticles
Neuromodulation enabled by light-sensitive nanoparticles
Rebuilding the brain after a stroke
Bleeding controlled with snake venom
HIV drug repurposed for memory loss treatment
Antibacterial surface coating makes medical devices safer