This review focuses on classical and state‐of‐the‐art methods for the identification and quantification of RNA molecules in a variety of subcellular locations.
WIREs RNA
The Emerging Importance of Non-Coding RNAs in Insecticide Tolerance
Regulatory noncoding RNAs (ncRNAs) are thought to play important roles in both the development and insecticide resistance of the diamondback moth.
Intriguing Circles: Conflicts and Controversies in Circular RNA
Circular RNAs (circRNAs) are covalently closed RNA circles and have become a favorite research topic.
RNA and Cancer Biology
A fundamental challenge in the study of cancer biology is to uncover molecular mechanisms that lead to malignant cellular transformation.
Extracellular RNA in Viral–Host Interactions: Thinking Outside the Cell
Small RNAs and their associated RNA interference (RNAi) pathways underpin diverse mechanisms of gene regulation and genome defense across all three kingdoms of life and are integral to virus–host interactions.
Writing a Wrong: Coupled RNA Polymerase II Transcription and RNA Quality Control
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co‐transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3′ end processing of different RNA species to help ensure quality control of the transcriptome.
miR-146a-5p: Expression, Regulation, and Functions in Cancer
Novel findings suggest that miR‐146a‐5p may be useful as a noninvasive biomarker and as a targeted therapeutic in several cancers.
The Tandem Zinc Finger RNA Binding Domain of Members of the Tristetraprolin (TTP) Protein Family
Proteins with similar domain structures and activities have been found throughout eukaryotes, demonstrating that this protein family arose from an ancient ancestor.
Stress-Induced mRNP Granules: Form and Function of P-bodies and Stress Granules
In response to stress, cells must quickly reprogram gene expression to adapt and survive. This is achieved in part by altering levels of mRNAs and their translation into proteins.
RNAs in the Spliceosome: Insights from CryoEM Structures
Recent high‐resolution cryoEM structures of various spliceosomal complexes reveal unprecedented details of this large molecular machine.
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