Cytometry Part A has recently published Part II of Special Issue on High Throughput and High Content Imaging and Cellular Informatics guest edited by Graham D. Wright, Alex M. Ward, Frederic Bard and Meredith E.K. Calvert.
On September 29, 2017, the Advanced Science News article, High throughput and high content imaging special issue, highlighted the importance of High Throughput and High Content Imaging (HT/HC Imaging) in biological and biomedical research, bioengineering and drug discovery. In the editorial for Part I of this special issue, the guest editors discussed four areas that brought HT/HC Imaging to where it is today: (i) Reagents and assay tools, and the latest gene editing breakthroughs; (ii) Microscopy and optical advancements, and superresolution microscopy; (iii) Automation and robotics; and (iv) Computational advancements.
In their editorial for Part II “Pushing the boundaries of high content imaging” Graham D. Wright, Alex M. Ward, Frederic Bard and Meredith E.K. Calvert continue exploring the topic of HT/HC imaging and three criteria used to assess microscopy performance: (i) speed, (ii) Resolution, and (iii) sensitivity. Despite all above mentioned technological advances, the perfect instrument for optimal performance in each criterion is yet to be created. For this reason, the guest editors have drawn the ubiquitous triangle of compromise which, hopefully, will be resolved in the near future.
This is a Special Issue in two parts. The recently published Part II features three reviews and two original research articles. Each of five articles describes assay, technological or computational developments that work toward improving HC imaging for varied applications.