Although the overall functionality of Cas9 and Cas12a is remarkably similar, their distinct structural features result in distinct molecular mechanisms that impact their activities.
Results for "DNA"
Seeing from a Nanoelectrochemical Confined World
Electrochemical confined effects are capable of exploring the novel detection mechanisms of nanopore to efficiently convert the dynamic function/structure of single molecules into the ionic signatures or optical patterns. This will prompt the nanopore to emerge on the comprehensive range of future applications in both life and material science.
Journal of Polymer Science Award Winner: Rachel O’Reilly
The Journal of Polymer Science Innovation Award is now in its seventh year, and we are delighted to honor Rachel O’Reilly.
Targeting RNA in Mammalian Systems with Small Molecules
Small molecules have been used to study several mammalian RNA elements in disease. These advances encourage exploration of newly discovered RNA interactions with therapeutic potential.
What is happening in Polymer Science?
Each year, the editors of Wiley’s Macromolecular Journals select the best content published in the journals to be featured in a special collection, the Best of Macromolecular Journals.
![Trans-Scale Biosensing Interface for Ultrasensitive Detection [Video]](https://www.advancedsciencenews.com/wp-content/uploads/2018/04/adfm201706981_ASN_image.jpg)
Trans-Scale Biosensing Interface for Ultrasensitive Detection [Video]
Dr. Fan Yang and Prof. Guo-Jun Zhang from Hubei University of Chinese Medicine, and co-workers, engineer a trans-scale biosensing interface capable of ultrasensitive microRNA detection.
Genetic Variants in mRNA Untranslated Regions
Discussing the mechanisms of UTR regulation, the role of genetic variants in modulating RNA processing, and protein production in human disease.
Multipartite Designer Nanoparticles for Theranostic Applications
Multipartite designer nanoparticles are formed from the phage lambda decoration protein and can be used in a variety of theranostic applications.
Hematopoiesis in the Bone Marrow Microenvironment: Of Cells, their Interactions, and Therapeutic Opportunities
Recent findings on the roles and identity of the bone marrow microenvironment and how these niches might be targeted in the case of diseases are discussed.
“Golden Age” of Molecular Microbiology: Understanding Freshwater Microbial Communities
In the “golden age” of molecular microbiology, modern molecular tools enable researchers to understand freshwater microbial communities in unprecedented detail by identifying and enumerating them, as well as determining their activity in the environment.
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