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Tracing the Sources of the Nile Water

From the West African rain forest to the Ethiopian highlands, implications of changes in the West African rainforest with respect to the rain and available water resources of the Nile basin.

The Complex Enzymology Of mRNA Decapping

The Complex Enzymology Of mRNA Decapping

Single stranded RNAs with a free 5′ monophosphate end are susceptible to rapid degradation. Transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs) are stabilized by hairpin structures and by “hiding” their 5′ ends within complex protein structures.

Context-Dependent Regulation of Receptor Tyrosine Kinases

Context-Dependent Regulation of Receptor Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the ability to sense proteins in their environments. Many RTKs are essential to development and organ growth. Derangement of RTKs—by mutation or by overexpression—is central to several developmental and adult disorders including cancer, short stature, and vascular pathologies.

Beyond the Horizon of CMOS

Beyond the Horizon of CMOS

For decades the density of integrated circuits has grown exponentially, according to the empirical Moore´s law published in 1965. In this period, the storage density has increased by a factor of about 100 million. Yet, this rapid development is approaching fundamental...