Lead Optimization for Medicinal Chemists

The Drug Discovery Process
Lead Optimization

PART II: THE PHARMACOKINETIC PROPERTIES OF COMPOUND CLASSES

Alkanes
Alkenes and Alkynes
Arenes
Halides
Azides
Nitro Compounds
Azo Compounds
Triazenes
Nitrates and Nitrites
N-Nitroso Compounds
N-Oxides
Alcohols
Phenols
Ethers
Epoxides
Peroxides
Thiols
Thioethers
Sulfoxides
Sulfones
Aliphatic Amines
Quaternary Ammonium Salts
Amidines
Guanidines, Acylguanidines, and Biguanides
Anilines
Hydrazines, Acylhydrazines, and Hydrazones
Aldehydes
Ketones
Carboxylic Acids
Carboxylic Esters
Amides
Lactams and Imides
Nitriles
Carbonates
Carbamates
Ureas
Thiocarbonyl Compounds
Sulfonic Acids
Sulfonic Esters
Sulfates and Sulfamic Acids
Phosphonic Acids
Phosphoric Acid Derivatives
N-(Aminoalkyl)benzamides, -benzoates, and Related Compounds
Arylalkylamines
Phenethylamines (2-phenylethylamines)
Aminoalkylindoles and Indole Alkaloids
Pehenothiazines
Dibenzazepines and Related Tricyclic Compounds
3-Aryloxy-2-Hydroxypropylamines (ß-Adrenergic Antagonists; ‘Beta Blockers’)
Opiates
N-(Carboxyalkyl)-alpha-Amino Acid Amides (Prils)
Anilides and Amindes of Glycine
Peptides, Peptidomimetics, and Related Oligoamides
Oligoarylamines, -amides, -carbamates, and -ureas
Imidazoles
Triazoles
Pyridines, Pyrimidines, and Related Compounds
Quinolines
Nucleoside Analogs
Dihydropyridines
Arenesulfonamides
[XVI, 606 Pages, Hardcover]

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