WIREs Authors
The award-winning Wiley Interdisciplinary Reviews series combines some of the most powerful features of encyclopedic reference works and review journals in an innovative online format.
Methylated Cytosine: A Promising Regulator of RNA Function?

Methylated Cytosine: A Promising Regulator of RNA Function?

It is a well‐known fact that RNA is the target of a plethora of modifications which currently amount to over a hundred. The vast majority of these modifications was observed in the two most abundant classes of RNA, rRNA and tRNA. With the recent advance in mapping technologies, modifications have been discovered also in mRNA and in less abundant non‐coding RNA species.

Context-Dependent Regulation of Receptor Tyrosine Kinases

Context-Dependent Regulation of Receptor Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are cell membrane proteins that provide cells with the ability to sense proteins in their environments. Many RTKs are essential to development and organ growth. Derangement of RTKs—by mutation or by overexpression—is central to several developmental and adult disorders including cancer, short stature, and vascular pathologies.