WIREs Systems Biology and Medicine
Virtual Endovascular Treatment of Intracranial Aneurysms: Models and Uncertainty

Virtual Endovascular Treatment of Intracranial Aneurysms: Models and Uncertainty

Virtual endovascular treatment models (VETMs) have been developed with the view to aid interventional neuroradiologists and neurosurgeons to pre-operatively analyse the comparative efficacy and safety of endovascular treatments for intracranial aneurysms. Current deterministic computational simulations need to be extended with strategies for uncertainty mitigation, uncertainty exploration, and sensitivity reduction techniques.

Insights into Nuclear Dynamics using Live-Cell Imaging Approaches

Insights into Nuclear Dynamics using Live-Cell Imaging Approaches

CRISPR is a newly developed, but rapidly advancing, genome editing technique that has advanced the nuclear imaging field by providing a means to fluorescently label a dead Cas9 protein fused with green fluorescent protein (dCas9-GFP), allowing scientists to microscopically track where certain proteins bind to the DNA.