Diagnostics - Disease Prevention - Regenerative Medicine - Therapeutics

Most Read – Featuring Vaccination Strategies, Skin-Based Devices and More

April’s top Advanced Healthcare Materials papers.

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In this monthly feature, we highlight some of the most read Advanced Healthcare Materials papers over the last month. These top-downloaded papers are therefore currently freely accessible! Click on the headers below to get to the corresponding papers. Also check out our previous monthly cover art feature here.

Toward a Single‐Dose Vaccination Strategy with Self‐Encapsulating PLGA Microspheres

by Brittany A. Bailey, Lukasz J. Ochyl, Steven P. Schwendeman, and James J. Moon

James Moon and his team at the University of Michigan developed a “self-encapsulating” procedure that maintains antigenicity and immunogenicity of protein antigens during the synthesis of PLGA microspheres. A single-dose immunization with microspheres designed for antigen release over more than 40 days elicits robust cellular and humoral immune responses in mice as efficiently as the prime-boost immunizations with a routinely-used adjuvant. The proposed “self-encapsulating” particles show great vaccine potential.

Advanced Materials for Health Monitoring with Skin-Based Wearable Devices

by Han Jin, Yasmin Shibli Abu-Raya, and Hossam Haick

The interest in skin-based wearable devices has been growing due to their potential use in diagnostics and health monitoring. In their review, Hossam Haick and colleagues from the Technion – Israel Institute of Technology in Haifa give a comprehensive overview of material characteristics and recent technologies used in these healthcare devices, as well as fabrication methods and applications. They not only describe the current achievements and obstacles in the field, but also offer a thorough discussion for further improvement of skin-based wearable devices.

Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements

by Dmitry Kireev, Silke Seyock, Johannes Lewen, Vanessa Maybeck, Bernhard Wolfrum, and Andreas Offenhäusser

Andreas Offenhäusser at the Institute of Bioelectronics in Jülich, Germany and his collaborators present graphene multielectrode arrays for cardiac and neuronal extracellular recordings. These arrays are implemented to study classic cellular cultures, such as the cardiac-like cell line HL-1 and more complex cortical neuronal cultures. They show an excellent ability to extracellularly detect action potentials, with signal-to-noise ratios of up to 116 for HL-1 cells and up to 100 for spontaneous bursting/spiking neuronal activity. The arrays have great potential in bioelectronics applications, and could be successful electrophysiological tools in the future.

3D Printing of Scaffolds for Tissue Regeneration Applications

by Anh-Vu Do, Behnoush Khorsand, Sean M. Geary, and Aliasger K. Salem

3D printing for tissue engineering and regenerative medicine continues to be a very popular topic in the field. Aliasger Salem et al. from the University of Iowa provide a state-of-the-art review on 3D printing of viable and functional scaffolds. In contrast to other available reviews that look at printing cells and tissues, this review focuses on different synthetic scaffolding materials and printing methods.

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

by Anirudha Singh, David Lee, Nikolai Sopko, Hotaka Matsui, Praveena Sabnekar, Xiaopu Liu, Jennifer Elisseeff, Mark P. Schoenberg, Kenneth Pienta, and Trinity J. Bivalacqua

A group of researchers led by Anirudha Singh at Johns Hopkins University in Baltimore report on an innovative process to manufacture continuous and seamless collagen scaffolds that can recapitulate the structural design and biomechanical properties of hollow and tubular organs. Their approach allows precise control of the longitudinal, radial and cross-sectional planes of the scaffold, resulting in biomaterials ranging from micro-ureters to urinary conduits to small intestine-like tubes with villi- to alveolar sac-like structures. This process can potentially be used together with stem cells in (pre-)clinical settings, and may have an impact in genitourinary, gastrointestinal and tissue engineering applications.

An honorable mention goes to the following three papers, which also are among April’s top-downloaded Advanced Healthcare Materials papers and which we already highlighted here:

Electrical Differentiation of Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes using Inkjet Printed Graphene Circuits

by Suprem R. Das, Metin Uz, Shaowei Ding, Matthew T. Lentner, John A. Hondred, Allison A. Cargill, Donald S. Sakaguchi, Surya Mallapragada, and Jonathan C. Claussen

Biofunctionalized Plants as Diverse Biomaterials for Human Cell Culture

by Gianluca Fontana, Joshua Gershlak, Michal Adamski, Jae-Sung Lee, Shion Matsumoto, Hau D. Le, Bernard Binder, John Wirth, Glenn Gaudette, and William L. Murphy

Au Nanoclusters and Photosensitizer Dual Loaded Spatio-Temporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase

by Fuping Gao, Weiping Zheng, Liang Gao, Pengju Cai, Ru Liu, Yaling Wang, Qing Yuan, Yuliang Zhao, and Xueyun Gao

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