The journal Proteomics – Clinical Applications is now inviting submissions for a special issue, to be published in the autumn of 2018, on the topic Proteomics in Pathology.
Clinical proteomics is an emerging interdisciplinary research field that is in the direction towards application in pathology. Mass spectrometry (MS)-based proteomic approaches are very versatile for understanding molecular and cellular biology. They offer valuable resources to shed insight into mechanisms involved in disease development and progression, and therapeutic intervention.
Advances in tissue proteomics over the past decade have enabled analyses of formalin-fixed paraffin-embedded (FFPE) tissue samples, opening new opportunities for clinical studies and biomarker discovery using hospital biopsy libraries. Today, two key approaches in mass spectrometry are envisioned for routine pathology applications.
Matrix-assisted laser desorption/ionization (MALDI) profiling/imaging allows for the rapid investigation of molecular profiles from hundreds of patients within one analysis. It also allows the retrieval of the spatial distribution of biocompounds through tissue sections. This method holds good promise for tissue typing in routine diagnosis.
The second approach using LC-MS/MS-based proteomics enables high-throughput identification and quantification of proteins from limited amounts of tissue material. Recent developments allowed highly informative studies of FFPE tissues to be performed containing less than 3000 cells. While being extremely robust for biomarker discovery, it is also expected to be one of the methods of choice for proteomic pathology.
Information gained from such complementary technologies may soon exert a spectacular change in the field of pathology and impact dramatically on patients’ care. In the near future, MS-based proteomics should significantly improve our ability to perform early diagnoses, personalized therapy, and monitor response to therapy.
To highlight cutting-edge studies and progress in this area, we are pleased to announce a special issue on Proteomics in Pathology, which will be dedicated to every aspect of MS-based proteomics having an impact in pathology such as diagnosis, prognosis, prediction to therapy, and biomarker discovery. Dr. Rémi Longuespée, from University of Heidelberg, Dr. Rita Casadonte, from Proteopath GmbH, Dr. Kristina Schwamborn, from Technical University of Munich, and Dr. Mark Kriegsmann, University of Heidelberg, are the guest editors for this issue.
Topics may include (but not be limited to):
- Proteomics in clinical diagnostics and personalized medicine
- Biomarkers development and implementation
- Data mining and analysis
- Technologies development in the field of ‘omics’
All manuscript formats will be considered, including Research Articles, Review Articles, Technical Briefs, Dataset Briefs and Viewpoint Articles. Regular submission due date is March 1st, 2018.
Authors can submit their manuscripts via the manuscript submission site at https://mc.manuscriptcentral.com/clinical.
For further information, please contact us:
Dr. Rémi Longuespée ([email protected])
Dr. Rita Casadonte ([email protected])
Dr. Kristina Schwamborn ([email protected])
Dr. Mark Kriegsmann ([email protected])
Editorial office ([email protected])
Text kindly provided by guest editors, Dr. Rita Casadonte and Dr. Rémi Longuespée.