Iron: The Life Story

by | Mar 1, 2017

The iron biochemistry from the point of view of inorganic and physical chemistry is discussed in a new review.

Iron, by mass, is the second most abundant element after aluminum and the fourth most abundant element in the Earth’s crust. Also, it’s one of the most important elements that sustain life. Since the dawn of life 3,500 Ma, it has partaken in various roles:

  • Plants use it to produce chlorophyll for photosynthesis.
  • Invertebrates and vertebrates use hemeproteins such as hemeerythrin, hemoglobin, and myoglobin to transport and store oxygen in their cells and tissues.
  • Nearly all cell-based organisms use hemeproteins called cytochromes to generate energy in the form of ATP (adenosine triphosphate) and in metabolic pathways that produce valuable chemicals like alkanes, olefins, and alcohols.

And this is only a short list of the biological processes and functions iron is involved in.
In this IUBMB Life reviewJose M. Dominguez-Vera and co-workers at the University of Granada Department of Inorganic Chemistry discuss the iron biochemistry from the point of view of inorganic and physical chemistry.

The coordination and electrochemical properties of iron and its abundance in the environment make it relevant to biology. Iron primarily exists in two oxidation states – insoluble Fe3+ and soluble Fe2+, and intermediate high-valent Fe(VI) and Fe(V) generated during different stages of biocatalysis. Before the “Great Oxygen Event” 2,500 Ma, the Earth’s atmosphere was reductive and most iron was soluble, facilitating its integration into the living systems. After this groundbreaking event, the water now only contains Fe3+ , which is detrimental to a cellular health in more than one way. Most cell-based organisms had to adapt to a new world and the authors describe how it was achieved in this detailed and concise review.


ASN Weekly

Sign up for our weekly newsletter and receive the latest science news.

Related posts: