Stem Cell Research and Therapies – Advanced Healthcare Materials Virtual Issue

Stem Cell Research and TherapiesWithStem Cell Research and Therapies their two key features – capacity for indefinite proliferation (self-renewal) and ability to give rise to different cell types (potency) – stem cells have fascinated scientists since the late nineteenth century. In addition to embryonic and adult stem cells, mature cells can be reprogrammed to act as stem cells, the so-called induced pluripotent stem cells (iPS cells), a finding that received the Nobel Prize in Physiology or Medicine in 2012. With the discovery of iPS cells, research into utilization of stem cells for understanding developmental processes, disease mechanisms, and for drug discovery and cell-based therapies such as regenerative medicine has gained momentum. However, before stem cells can be used efficiently, there are still a number of obstacles, such as regulation of stem cell behavior and long-term maintenance of “stemness”, which must be overcome. A significant contribution to this end comes from materials science, whereby biomaterial scaffolds, cell culture and encapsulation technologies as well as engineering stem cells and matrices provide the means to regulate stem cell responses. Progress in these fields also advances stem cell-based therapies such as regeneration of cardiac, neural, and orthopedic tissues.

Advanced Healthcare Materials covers different aspects of stem cell research and therapies with a focus on biomaterials. We have assembled this virtual issue to highlight some of the excellent research being published in this field. All articles are currently freely available for everybody to access, download, and read until the end of 2018.


Review articles:

Biomechanical Regulation of Mesenchymal Stem Cells for Cardiovascular Tissue Engineering

Kayla Henderson, Andrew D. Sligar, Victoria P. Le, Jason Lee and Aaron B. Baker

Nano‐Enabled Approaches for Stem Cell‐Based Cardiac Tissue Engineering

Mahshid Kharaziha, Adnan Memic, Mohsen Akbari, David A. Brafman and Mehdi Nikkhah

Engineering Stem Cells for Biomedical Applications

Perry T. Yin, Edward Han and Ki-Bum Lee

Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments

Amaia Cipitria and Manuel Salmeron‐Sanchez

Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future

Giada Graziana Genchi, Attilio Marino, Agostina Grillone, Ilaria Pezzini and Gianni Ciofani


Original research articles:

Liposome‐Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post‐Transplantation In Vivo

Mariarosa Mazza, Neus Lozano, Debora Braga Vieira, Maurizio Buggio, Cay Kielty and Kostas Kostarelos

Hydrogel Encapsulation Facilitates Rapid‐Cooling Cryopreservation of Stem Cell‐Laden Core–Shell Microcapsules as Cell–Biomaterial Constructs

Gang Zhao, Xiaoli Liu, Kaixuan Zhu and Xiaoming He

Droplet Microarray Based on Patterned Superhydrophobic Surfaces Prevents Stem Cell Differentiation and Enables High‐Throughput Stem Cell Screening

Tina Tronser, Anna A. Popova, Mona Jaggy, Martin Bastmeyer and Pavel A. Levkin

Controlled Exposure of Bioactive Growth Factor in 3D Amyloid Hydrogel for Stem Cells Differentiation

Subhadeep Das, Rakesh Kumar, Narendra Nath Jha and Samir K. Maji

Microcarriers with Synthetic Hydrogel Surfaces for Stem Cell Expansion

Andrew D. Dias, Jonathan M. Elicson and William L. Murphy

Spatially Assembled Bilayer Cell Sheets of Stem Cells and Endothelial Cells Using Thermosensitive Hydrogels for Therapeutic Angiogenesis

Indong Jun, Taufiq Ahmad, Seongwoo Bak, Joong‐Yup Lee, Eun Mi Kim, Jinkyu Lee, Yu Bin Lee, Hongsoo Jeong, Hojeong Jeon and Heungsoo Shin


For other virtual issues of Advanced Healthcare Materials, please click on the pictures below:

Diagnostic Devices for Healthcare     Nanotherapeutics

Regenerative Medicine     Biofabrication for Tissue Engineering