Nanotherapeutics – Advanced Healthcare Materials Virtual Issue

NanotherapeuticsAmongNanotherapeutics the greatest challenges facing modern medicine is the problem of administering targeted, potent therapeutics to the desired tissues. Selectively treating the diseased cells, while sparing the healthy ones, would greatly diminish side effects or dosing problems, but it has been only recently that new strategies have emerged that are capable of achieving these effects. One promising strategy is the use of nanotechnology to miniaturize drug delivery systems into so-called nanotherapeutics.

In general, the development of new nanotherapies must address four key challenges. The first is the overall design of the system. Nanotherapeutics must be relatively stable, non-toxic, biocompatible, and multifunctional, capable of encapsulating or incorporating their drug payloads. Second, nanotherapeutics require some way to target their intended cells or receptors, thus concentrating at their intended site within the body. Third, once localized to their targets, the delivery system needs a way to release the drugs or diagnostic molecules in a controlled fashion. And finally, after their payloads are successfully delivered, the system must have a way to be cleared from the body to avoid concerns over long-term exposure.

In this virtual issue of Advanced Healthcare Materials, we highlight some of the recent reports and developments in these four nanotherapeutic features, showcasing how chemistry, nanotechnology, and materials science combine at the small scale to benefit medicine at large. All articles are currently freely available for everybody to access, download, and read until the end of 2018.

 

Review articles:

Cyanine based Nanoprobes for Cancer Theranostics

Pravin Bhattarai and Zhifei Dai

Bisphosphonate‐Functionalized Imaging Agents, Anti‐Tumor Agents and Nanocarriers for Treatment of Bone Cancer

Robin A. Nadar, Nicola Margiotta, Michele Iafisco, Jeroen J. J. P. van den Beucken, Otto C. Boerman and Sander C. G. Leeuwenburgh

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

Helena Knopf-Marques, Martin Pravda, Lucie Wolfova, Vladimir Velebny, Pierre Schaaf, Nihal Engin Vrana and Philippe Lavalle

Design Advances in Particulate Systems for Biomedical Applications

Ana Catarina Lima, Carmen Alvarez-Lorenzo and João F. Mano

Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials

Duarte de Melo‐Diogo, Cleide Pais‐Silva, Diana R. Dias, André F. Moreira and Ilídio J. Correia

Rational Design of Biomolecular Templates for Synthesizing Multifunctional Noble Metal Nanoclusters toward Personalized Theranostic Applications

Yong Yu, Beverly Y. L. Mok, Xian Jun Loh and Yen Nee Tan

 

Original research articles:

Self‐Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Yunlu Dai, Junling Guo, Ting‐Yi Wang, Yi Ju, Andrew J. Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J. Richardson, Christoph E. Hagemeyer, Karen Alt and Frank Caruso

Ebola Vaccination Using a DNA Vaccine Coated on PLGA‐PLL/γPGA Nanoparticles Administered Using a Microneedle Patch

Hung‐Wei Yang, Ling Ye, Xin Dong Guo, Chinglai Yang, Richard W. Compans and Mark R. Prausnitz

Ultrasound‐Enhanced siRNA Delivery Using Magnetic Nanoparticle‐Loaded Chitosan‐Deoxycholic Acid Nanodroplets

Jeong Yu Lee, Calum Crake, Boon Teo, Dario Carugo, Marie de Saint Victor, Anjali Seth and Eleanor Stride

Nuclear‐Targeted Multifunctional Magnetic Nanoparticles for Photothermal Therapy

Haibao Peng, Jing Tang, Rui Zheng, Guannan Guo, Angang Dong, Yajun Wang and Wuli Yang

 

For other virtual issues of Advanced Healthcare Materials, please click on the pictures below:

Regenerative Medicine     Biofabrication for Tissue Engineering

Stem Cell Research and Therapies     Diagnostic Devices for Healthcare