Recent advances in single‐molecule techniques have led to new discoveries in analytical chemistry, biophysics, and medicine. Understanding the structure and behavior of single biomolecules provides a wealth of information compared to studying large ensembles.
Scalable Method to Generate Human iPSC-Derived Macrophages
Protocol for iPSC-derived macrophages with excellent functional and transcriptomic fidelity.
Surviving Phosphate Limitation via the C-P Lyase Pathway
The mechanisms for how bacteria break down phosphonates in order to overcome times of phosphate limitation.
RNAs in the Spliceosome: Insights from CryoEM Structures
Recent high‐resolution cryoEM structures of various spliceosomal complexes reveal unprecedented details of this large molecular machine.
Organotypic Culture System for in vitro Bone Modeling
An organotypic culture system that allows the production of bone tissue features on a centimeter scale.
Mitochondria-Targeting Protein Nanoparticles for Cancer Therapies
Self-assembling protein nanoparticles that target the mitochondria and rapidly accumulate in tumors have potential for combination therapies.
When Multi-Subunit Complexes Meet: Replisome-Cohesin Interactions at the Replication Fork
Exploring cohesin and replisome interactions during DNA replication.
Microtruck Delivery Service: Transporting Microcargo using Amoeboid Cells
Amoeboid cell microtransporters carry microcargo in an independent, self-organized fashion.
Rnt1p: An Alternative to RNAi for Targeted RNA Degradation
The double‐stranded RNA‐binding protein family controls RNA editing, stability, and function in all eukaryotes.
Mimicking Healthy and Diseased Cell Environments
Research suggests that epigenetic remodeling can be persistent and might be a memory keeper.