Best of Macros 2017: Wim Hennink

Wim Hennink obtained his Ph.D. degree at Twente University of Technology in 1985. From 1985 until 1992, he held different positions in industry, and in 1992 he was appointed as Professor at the Faculty of Pharmacy of the University of Utrecht. From 1996 onwards, he has been head of the Department of Pharmaceutics at this university. From 2012–2015, he was scientific director of the Utrecht Institute for Pharmaceutical Sciences (UIPS) and since September 2015 he has been head of the Department of Pharmaceutical Sciences. His main research interests are in the field of polymeric drug delivery systems. He has published over 520 papers and book chapters and is the inventor of 20 patents.

His article “Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery” in Macromolecular Bioscience has been selected for this year’s Best of Macros.

Ask the Author

Why did your choose the area of macromolecular science? Our research focuses on the design of biodegradable polymers for pharmaceutical and biomedical applications. In our team, researchers with different backgrounds collaborate on fundamental questions but we have an open eye for possible applications of the different technologies we develop.

What future opportunities do you see (in the light of the results presented in this paper)? Our review summarizes and discusses recent literature to design stable polymeric micelles. These systems have been shown to be suitable for the delivery of anticancer and anti-inflammatory agents, and clinical trials are ongoing. However, to fully exploit the possibilities of polymeric micelles for targeted drug delivery, their stability in the circulation should be improved. On the other hand, the systems should not be too stable because the release of the loaded therapeutic at the target site is hampered. So, the design of systems with controlled (in)stability is scientifically challenging, but once successful, clinical translation is possible given their relatively simple pharmaceutical production. 

My favourite molecule is… water. It is such a simple molecule with many unique properties. But importantly, life cannot be imagined without water.

What I look for first in a publication is… to the end of the Introduction. In good papers, a challenging aim is formulated there.

Physico-Chemical Strategies to Enhance Stability and Drug Retention of Polymeric Micelles for Tumor-Targeted Drug Delivery
Y. Shi, T. Lammers, G. Storm, W. E. Hennink*
Macromol. Biosci. 2017, 17, 1600160
DOI: 10.1002/mabi.201600160

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