Manufacturing - Regenerative Medicine

Researchers With a Soft Heart

ETH researchers have developed a silicone heart that beats almost like a human heart.

Currently used blood pumps have many disadvantages: their mechanical parts are susceptible to complications while the patient lacks a physiological pulse, which is assumed to have some consequences for the patient.

“Therefore, our goal is to develop an artificial heart that is roughly the same size as the patient’s own one and which imitates the human heart as closely as possible in form and function,” says Nicholas Cohrs. The doctoral student of the Swiss Federal Institute of Technology in Zurich (ETH Zurich) has developed a silicone heart that looks like a real heart.

A well-functioning artificial heart is a real necessity: about 26 million people worldwide suffer from heart failure while there is a shortage of donor hearts. Artificial blood pumps help to bridge the waiting time until a patient receives a donor heart or their own heart recovers.

The artificial heart imitates a human heart as closely as possible. Source: Zurich Heart

The soft artificial heart was created from silicone using a 3D-printing, lost-wax casting technique; it weighs 390 grams and has a volume of 679 cm3. “It is a silicone monoblock with complex inner structure,” explains Cohrs. This artificial heart has a right and a left ventricle, just like a real human heart, though they are not separated by a septum but by an additional chamber. This chamber is in- and deflated by pressurized air and is required to pump fluid from the blood chambers, thus replacing the muscle contraction of the human heart.

Anastasios Petrou, a doctoral student of the Product Development Group Zurich, evaluated the performance of this soft artificial heart. The young researchers have just published the results of the experiments in the journal Artificial Organs.

They proved that the soft artificial heart fundamentally works and moves in a similar way to a human heart. However, it still has one problem: it currently lasts for about only 3,000 beats, which corresponds to a lifetime of half to three quarters of an hour. After that, the material can no longer withstand the strain. Cohrs explains: “This was simply a feasibility test. Our goal was not to present a heart ready for implantation, but to think about a new direction for the development of artificial hearts.” Of course, the tensile strength of the material and the performance would have to be enhanced significantly.

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