Polymer therapeutics represent promising novel chemical entities under development for addressing CNS disorders, in which intravenous and intranasal administration are the most appealing strategies to achieve this paramount goal.
The Softer Side of Robots
A vibrotactile actuator and robotic gripper that operate based on the Lorentz force principle are demonstrated.
Chemically Engineered Fusion Proteins beyond Nature’s Machinery
Bioactive entities are combined into structurally ordered multidomain protein complexes to mitigate selective targeting of a hallmark protein molecule in cancer diseases.
Biofilm-Inspired Fabrication of Complex Nanostructures [Video]
Inspired by biofilm formation, a strategy for templated self-assembly of nano-objects is developed for the fabrication of complex nanostructures.
Droplet Microfluidics for High-Throughput Screening of Disease Biomarkers
The potential of rapid diagnostics and screening has led to burgeoning interest in droplets, as it is increasingly used to detect novel disease biomarker targets.
A Rapid In Situ Disinfection Method for Surgical Implants [Video]
A disinfection method for titanium implant surfaces using a hybrid coating of chitosan on molybdenum disulfide.
Structure–Function Comparisons and Implications for Genome Editing
Although the overall functionality of Cas9 and Cas12a is remarkably similar, their distinct structural features result in distinct molecular mechanisms that impact their activities.
Seeing from a Nanoelectrochemical Confined World
Electrochemical confined effects are capable of exploring the novel detection mechanisms of nanopore to efficiently convert the dynamic function/structure of single molecules into the ionic signatures or optical patterns. This will prompt the nanopore to emerge on the comprehensive range of future applications in both life and material science.
CRISPR-based Genome Editing via Non-Viral Delivery
This non-viral CRISPR-Cas9 delivery vector is ten times as effective at genome modification as the standard plasmid transfection techniques, down-regulating Plk1 expression over 70% to inhibit tumor growth.
Microbial Sensors Based on ZnO Nanorod Arrays [Video]
The size, shape, and order of nanorods in solid-state microbial sensors are controlled using the forces of gravity and magnetism.